Assay Detail
Functional
CHEMBL954872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.07 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182739 | — | — | 1 | 8.49 |
| CHEMBL505905 | — | — | 1 | 7.94 |
| CHEMBL499306 | — | — | 1 | 7.64 |
| CHEMBL506674 | — | — | 1 | 7.52 |
| CHEMBL275497 | — | — | 1 | 7.47 |
| CHEMBL526314 | — | — | 1 | 7.47 |
| CHEMBL493809 | — | — | 1 | 7.46 |
| CHEMBL506035 | — | — | 1 | 7.30 |
| CHEMBL525400 | — | — | 1 | 7.30 |
| CHEMBL447545 | — | — | 1 | 7.24 |
| CHEMBL499848 | — | — | 1 | 7.23 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.11 |
| CHEMBL493978 | — | — | 1 | 7.04 |
| CHEMBL452048 | — | — | 1 | 6.75 |
| CHEMBL499027 | — | — | 1 | 6.42 |
| CHEMBL497753 | — | — | 1 | 6.41 |
| CHEMBL443720 | — | — | 1 | 6.41 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.37 |
| CHEMBL493808 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182739 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL505905 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL499306 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL506674 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL275497 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL526314 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL493809 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL506035 | — | IC50 | = | 49.8 | nM | 7.30 |
| CHEMBL525400 | — | IC50 | = | 50.4 | nM | 7.30 |
| CHEMBL447545 | — | IC50 | = | 57.4 | nM | 7.24 |
| CHEMBL499848 | — | IC50 | = | 58.8 | nM | 7.23 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL493978 | — | IC50 | = | 91.8 | nM | 7.04 |
| CHEMBL452048 | — | IC50 | = | 175.7 | nM | 6.75 |
| CHEMBL499027 | — | IC50 | = | 384.2 | nM | 6.42 |
| CHEMBL497753 | — | IC50 | = | 385.4 | nM | 6.41 |
| CHEMBL443720 | — | IC50 | = | 393.5 | nM | 6.41 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL493808 | — | IC50 | = | 17180.0 | nM | 4.76 |