Assay Detail
Functional
CHEMBL954873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.95 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.89 |
| CHEMBL182739 | — | — | 1 | 7.89 |
| CHEMBL505905 | — | — | 1 | 7.61 |
| CHEMBL499306 | — | — | 1 | 7.61 |
| CHEMBL275497 | — | — | 1 | 7.59 |
| CHEMBL447545 | — | — | 1 | 7.51 |
| CHEMBL493809 | — | — | 1 | 7.48 |
| CHEMBL506035 | — | — | 1 | 7.36 |
| CHEMBL525400 | — | — | 1 | 7.26 |
| CHEMBL526314 | — | — | 1 | 7.26 |
| CHEMBL499848 | — | — | 1 | 7.26 |
| CHEMBL493978 | — | — | 1 | 6.89 |
| CHEMBL452048 | — | — | 1 | 6.52 |
| CHEMBL497753 | — | — | 1 | 6.42 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.30 |
| CHEMBL499027 | — | — | 1 | 6.23 |
| CHEMBL506674 | — | — | 1 | 6.02 |
| CHEMBL443720 | — | — | 1 | 5.75 |
| CHEMBL493808 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.274 | nM | 8.89 |
| CHEMBL182739 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL505905 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL499306 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL275497 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL447545 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL493809 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL506035 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL525400 | — | IC50 | = | 54.8 | nM | 7.26 |
| CHEMBL526314 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL499848 | — | IC50 | = | 54.8 | nM | 7.26 |
| CHEMBL493978 | — | IC50 | = | 127.9 | nM | 6.89 |
| CHEMBL452048 | — | IC50 | = | 303.1 | nM | 6.52 |
| CHEMBL497753 | — | IC50 | = | 378.1 | nM | 6.42 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL499027 | — | IC50 | = | 593.2 | nM | 6.23 |
| CHEMBL506674 | — | IC50 | = | 951.4 | nM | 6.02 |
| CHEMBL443720 | — | IC50 | = | 1789.0 | nM | 5.75 |
| CHEMBL493808 | — | IC50 | = | 64140.0 | nM | 4.19 |