Assay Detail
Functional
CHEMBL954874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MX1 cells after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MX1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.64 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.54 |
| CHEMBL182739 | — | — | 1 | 8.46 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.46 |
| CHEMBL452048 | — | — | 1 | 7.22 |
| CHEMBL275497 | — | — | 1 | 7.07 |
| CHEMBL443720 | — | — | 1 | 6.90 |
| CHEMBL493978 | — | — | 1 | 6.62 |
| CHEMBL505905 | — | — | 1 | 6.43 |
| CHEMBL493808 | — | — | 1 | 6.43 |
| CHEMBL499027 | — | — | 1 | 6.28 |
| CHEMBL499848 | — | — | 1 | 6.23 |
| CHEMBL499306 | — | — | 1 | 6.23 |
| CHEMBL493809 | — | — | 1 | 6.23 |
| CHEMBL506674 | — | — | 1 | 6.20 |
| CHEMBL497753 | — | — | 1 | 6.09 |
| CHEMBL506035 | — | — | 1 | 6.06 |
| CHEMBL525400 | — | — | 1 | 5.96 |
| CHEMBL526314 | — | — | 1 | 5.92 |
| CHEMBL447545 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL182739 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL452048 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL275497 | — | IC50 | = | 84.4 | nM | 7.07 |
| CHEMBL443720 | — | IC50 | = | 124.7 | nM | 6.90 |
| CHEMBL493978 | — | IC50 | = | 239.7 | nM | 6.62 |
| CHEMBL505905 | — | IC50 | = | 367.3 | nM | 6.43 |
| CHEMBL493808 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL499027 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL499848 | — | IC50 | = | 590.6 | nM | 6.23 |
| CHEMBL499306 | — | IC50 | = | 588.6 | nM | 6.23 |
| CHEMBL493809 | — | IC50 | = | 583.6 | nM | 6.23 |
| CHEMBL506674 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL497753 | — | IC50 | = | 810.1 | nM | 6.09 |
| CHEMBL506035 | — | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL525400 | — | IC50 | = | 1109.0 | nM | 5.96 |
| CHEMBL526314 | — | IC50 | = | 1203.0 | nM | 5.92 |
| CHEMBL447545 | — | IC50 | = | 1810.4 | nM | 5.74 |