Assay Detail
Functional
CHEMBL954875
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Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.91 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.89 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.74 |
| CHEMBL182739 | — | — | 1 | 8.19 |
| CHEMBL452048 | — | — | 1 | 7.22 |
| CHEMBL505905 | — | — | 1 | 7.13 |
| CHEMBL506674 | — | — | 1 | 6.96 |
| CHEMBL499306 | — | — | 1 | 6.80 |
| CHEMBL499848 | — | — | 1 | 6.73 |
| CHEMBL493808 | — | — | 1 | 6.67 |
| CHEMBL506035 | — | — | 1 | 6.62 |
| CHEMBL526314 | — | — | 1 | 6.59 |
| CHEMBL493809 | — | — | 1 | 6.58 |
| CHEMBL443720 | — | — | 1 | 6.58 |
| CHEMBL275497 | — | — | 1 | 6.47 |
| CHEMBL493978 | — | — | 1 | 6.36 |
| CHEMBL525400 | — | — | 1 | 6.30 |
| CHEMBL447545 | — | — | 1 | 6.24 |
| CHEMBL499027 | — | — | 1 | 6.09 |
| CHEMBL497753 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL182739 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL452048 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL505905 | — | IC50 | = | 74.9 | nM | 7.13 |
| CHEMBL506674 | — | IC50 | = | 110.2 | nM | 6.96 |
| CHEMBL499306 | — | IC50 | = | 158.1 | nM | 6.80 |
| CHEMBL499848 | — | IC50 | = | 187.8 | nM | 6.73 |
| CHEMBL493808 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL506035 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL526314 | — | IC50 | = | 256.3 | nM | 6.59 |
| CHEMBL493809 | — | IC50 | = | 264.5 | nM | 6.58 |
| CHEMBL443720 | — | IC50 | = | 262.6 | nM | 6.58 |
| CHEMBL275497 | — | IC50 | = | 340.8 | nM | 6.47 |
| CHEMBL493978 | — | IC50 | = | 437.4 | nM | 6.36 |
| CHEMBL525400 | — | IC50 | = | 495.6 | nM | 6.30 |
| CHEMBL447545 | — | IC50 | = | 571.2 | nM | 6.24 |
| CHEMBL499027 | — | IC50 | = | 815.5 | nM | 6.09 |
| CHEMBL497753 | — | IC50 | = | 899.8 | nM | 6.05 |