Assay Detail

CHEMBL954878

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human H1299 cells

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H1299
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.

Kapuriya N, Kapuriya K, Zhang X, Chou TC, Kakadiya R, Wu YT, Tsai TH, Chen YT, Lee TC, Shah A, Naliapara Y, Su TL.
Bioorg Med Chem (2008) 16 : 5413 -5423
PubMed 18450456 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.29	6.29

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL493978	—	—	1	6.29

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL493978	—	IC50	=	510.0	nM	6.29