Assay Detail
Binding
CHEMBL954907
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Inhibition of Mycobacterium tuberculosis recombinant TMPK
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 4.50 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222280 | BROXURIDINE | 2.0 | 1 | 5.30 |
| CHEMBL520293 | — | — | 1 | 5.19 |
| CHEMBL505732 | CHLORODEOXYURIDINE | — | 1 | 5.00 |
| CHEMBL189878 | — | — | 1 | 5.00 |
| CHEMBL193779 | — | — | 1 | 4.89 |
| CHEMBL483919 | — | — | 1 | 4.80 |
| CHEMBL519186 | — | — | 1 | 4.71 |
| CHEMBL484514 | — | — | 1 | 4.64 |
| CHEMBL484515 | — | — | 1 | 4.58 |
| CHEMBL449001 | — | — | 1 | 4.58 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 4.57 |
| CHEMBL449771 | — | — | 1 | 4.47 |
| CHEMBL482519 | — | — | 1 | 4.46 |
| CHEMBL482916 | — | — | 1 | 4.42 |
| CHEMBL189057 | — | — | 1 | 4.42 |
| CHEMBL482509 | — | — | 1 | 4.41 |
| CHEMBL483334 | — | — | 1 | 4.41 |
| CHEMBL482508 | — | — | 1 | 4.41 |
| CHEMBL190125 | — | — | 1 | 4.33 |
| CHEMBL454546 | — | — | 1 | 4.29 |
| CHEMBL526527 | — | — | 1 | 4.28 |
| CHEMBL189636 | — | — | 1 | 4.26 |
| CHEMBL520450 | — | — | 1 | 4.26 |
| CHEMBL482510 | — | — | 1 | 4.24 |
| CHEMBL448393 | — | — | 1 | 4.23 |
| CHEMBL485322 | — | — | 1 | 4.16 |
| CHEMBL520146 | — | — | 1 | 4.12 |
| CHEMBL364887 | — | — | 1 | 4.05 |
| CHEMBL482520 | — | — | 1 | 4.02 |
| CHEMBL485122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222280 | BROXURIDINE | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL520293 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL505732 | CHLORODEOXYURIDINE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL189878 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL193779 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL483919 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL519186 | — | Ki | = | 19500.0 | nM | 4.71 |
| CHEMBL484514 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL484515 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL449001 | — | Ki | = | 26500.0 | nM | 4.58 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL449771 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL482519 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL482916 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL189057 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL483334 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL482508 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL482509 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL190125 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL454546 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL526527 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL189636 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL520450 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL482510 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL448393 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL485322 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL520146 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL364887 | — | Ki | = | 89000.0 | nM | 4.05 |
| CHEMBL482520 | — | Ki | = | 96000.0 | nM | 4.02 |
| CHEMBL485122 | — | Ki | = | 112000.0 | nM | - |
| CHEMBL503907 | — | Ki | = | 202000.0 | nM | - |
| CHEMBL414848 | — | Ki | = | 195000.0 | nM | - |