Assay Detail
Functional
CHEMBL955099
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Inhibition of LPS-induced TNFalpha release in mouse RAW264.7 cells pretreated 1 hr before LPS challenge by enzyme immunoassay
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anti-inflammatory, and antioxidant activities of 18beta-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.99 | 5.89 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | 2.0 | 2 | 5.89 |
| CHEMBL450589 | — | — | 2 | 5.64 |
| CHEMBL508447 | — | — | 2 | 4.86 |
| CHEMBL474539 | — | — | 2 | 4.81 |
| CHEMBL493952 | — | — | 2 | 4.58 |
| CHEMBL44 | GENISTEIN | 2.0 | 2 | 4.58 |
| CHEMBL446812 | — | — | 2 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL450589 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL508447 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL474539 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL493952 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL44 | GENISTEIN | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL446812 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL230006 | ENOXOLONE | Inhibition | - | % | - | |
| CHEMBL493952 | — | Inhibition | - | % | - | |
| CHEMBL508447 | — | Inhibition | - | % | - | |
| CHEMBL474539 | — | Inhibition | - | % | - | |
| CHEMBL450589 | — | Inhibition | - | % | - | |
| CHEMBL446812 | — | Inhibition | - | % | - | |
| CHEMBL44 | GENISTEIN | Inhibition | - | % | - |