Assay Detail
Binding
CHEMBL955667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.48 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412923 | — | — | 1 | 10.17 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 8.94 |
| CHEMBL471806 | — | — | 1 | 8.54 |
| CHEMBL505960 | — | — | 1 | 7.83 |
| CHEMBL499141 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412923 | — | Ki | = | 0.067 | nM | 10.17 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL471806 | — | Ki | = | 2.86 | nM | 8.54 |
| CHEMBL505960 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL499141 | — | Ki | = | 115.0 | nM | 6.94 |