Assay Detail
Binding
CHEMBL955899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from alpha1 adrenergic receptor in rat cerebral cortex by liquid scintillation method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol and its enantiomers. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.50 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 8.66 |
| CHEMBL477466 | — | — | 1 | 7.25 |
| CHEMBL477465 | — | — | 1 | 7.05 |
| CHEMBL477672 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL723 | CARVEDILOL | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL477466 | — | Ki | = | 56.7 | nM | 7.25 |
| CHEMBL477465 | — | Ki | = | 89.8 | nM | 7.05 |
| CHEMBL477672 | — | Ki | = | 88.3 | nM | 7.05 |