Assay Detail
Binding
CHEMBL955901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP12177 from beta-1 adrenergic receptor in rat cerebral cortex by liquid scintillation method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol and its enantiomers. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.29 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 9.09 |
| CHEMBL477466 | — | — | 1 | 8.70 |
| CHEMBL477465 | — | — | 1 | 8.52 |
| CHEMBL477672 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL723 | CARVEDILOL | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL477466 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL477465 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL477672 | — | Ki | = | 143.0 | nM | 6.84 |