Assay Detail
Binding
CHEMBL955912
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Inhibition of human IGF1R phosphorylation expressed in HEK293 cells by DELFIA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.71 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475884 | — | — | 1 | 7.42 |
| CHEMBL476259 | GSK-1326255A | — | 1 | 7.33 |
| CHEMBL475073 | — | — | 1 | 7.28 |
| CHEMBL477069 | GSK-1173862A | — | 1 | 7.22 |
| CHEMBL458865 | GSK-1220512A | — | 1 | 7.22 |
| CHEMBL514615 | — | — | 1 | 7.19 |
| CHEMBL477950 | — | — | 1 | 7.17 |
| CHEMBL514828 | — | — | 1 | 7.15 |
| CHEMBL476044 | — | — | 1 | 7.09 |
| CHEMBL464971 | — | — | 1 | 7.05 |
| CHEMBL475286 | — | — | 1 | 7.05 |
| CHEMBL514868 | — | — | 1 | 6.98 |
| CHEMBL507625 | — | — | 1 | 6.96 |
| CHEMBL476059 | — | — | 1 | 6.91 |
| CHEMBL459069 | — | — | 1 | 6.89 |
| CHEMBL515602 | — | — | 1 | 6.87 |
| CHEMBL516816 | — | — | 1 | 6.80 |
| CHEMBL475883 | — | — | 1 | 6.72 |
| CHEMBL463932 | — | — | 1 | 6.67 |
| CHEMBL465374 | — | — | 1 | 6.57 |
| CHEMBL1964272 | — | — | 1 | 6.50 |
| CHEMBL475074 | — | — | 1 | 6.43 |
| CHEMBL473254 | — | — | 1 | 6.24 |
| CHEMBL475482 | — | — | 1 | 6.21 |
| CHEMBL505983 | — | — | 1 | 6.19 |
| CHEMBL511013 | — | — | 1 | 6.12 |
| CHEMBL473669 | — | — | 1 | 5.65 |
| CHEMBL515909 | — | — | 1 | 5.43 |
| CHEMBL450071 | GSK-1392956A | — | 1 | 5.25 |
| CHEMBL472846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475884 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL476259 | GSK-1326255A | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL475073 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL477069 | GSK-1173862A | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL458865 | GSK-1220512A | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL514615 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL477950 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL514828 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL476044 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL464971 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL475286 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL514868 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL507625 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL476059 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL459069 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL515602 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL516816 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL475883 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL463932 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL465374 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1964272 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL475074 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL473254 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL475482 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL505983 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL511013 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL473669 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL515909 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL450071 | GSK-1392956A | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL472846 | — | IC50 | > | 10000.0 | nM | - |