Assay Detail
Functional
CHEMBL955948
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Induction of osteogenesis in mouse MC3T3-E1 cells assessed as calcium level at 25 uM after 3 weeks
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MC3T3-E1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small molecules with potent osteogenic-inducing activity in osteoblast cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.94 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409538 | — | — | 1 | 7.52 |
| CHEMBL411091 | — | — | 1 | 7.30 |
| CHEMBL476459 | — | — | 1 | 7.05 |
| CHEMBL476073 | — | — | 1 | 6.82 |
| CHEMBL515779 | — | — | 1 | 6.68 |
| CHEMBL478903 | — | — | 1 | 6.29 |
| CHEMBL478904 | — | — | 1 | - |
| CHEMBL476074 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409538 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL411091 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL476459 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL476073 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL515779 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL478903 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL478904 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL476074 | — | EC50 | > | 20000.0 | nM | - |