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Assay Detail

CHEMBL956074

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.
Sentürk M, Gülçin I, Daştan A, Küfrevioğlu OI, Supuran CT.
Bioorg Med Chem (2009) 17 : 3207 -3211
PubMed 19231207 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 4.25 4.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 4.44
CHEMBL1662 1 4.43
CHEMBL478518 1 4.42
CHEMBL507918 1 4.25
CHEMBL13766 GUAIACOL 3.0 1 4.22
CHEMBL98253 1 4.20
CHEMBL449983 1 4.03
CHEMBL526 PROPOFOL 4.0 1 4.00
CHEMBL30106 1 -
CHEMBL281071 1 -
CHEMBL146 BUTYLATED HYDROXYTOLUENE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 36200.0 nM 4.44
CHEMBL1662 Ki = 37500.0 nM 4.43
CHEMBL478518 Ki = 37900.0 nM 4.42
CHEMBL507918 Ki = 55600.0 nM 4.25
CHEMBL13766 GUAIACOL Ki = 60200.0 nM 4.22
CHEMBL98253 Ki = 63700.0 nM 4.20
CHEMBL449983 Ki = 92800.0 nM 4.03
CHEMBL526 PROPOFOL Ki = 98900.0 nM 4.00
CHEMBL30106 Ki = 198300.0 nM -
CHEMBL281071 Ki = 274500.0 nM -
CHEMBL146 BUTYLATED HYDROXYTOLUENE Ki = 245200.0 nM -