Assay Detail
Binding
CHEMBL956501
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Inhibition of IRAK4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.43 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258004 | — | — | 1 | 7.46 |
| CHEMBL255272 | — | — | 1 | 7.16 |
| CHEMBL485324 | — | — | 1 | 6.70 |
| CHEMBL255098 | — | — | 1 | 6.67 |
| CHEMBL482708 | — | — | 1 | 6.40 |
| CHEMBL500069 | — | — | 1 | 6.34 |
| CHEMBL482709 | — | — | 1 | 5.92 |
| CHEMBL482522 | — | — | 1 | 5.71 |
| CHEMBL485323 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258004 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL255272 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL485324 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL255098 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL482708 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL500069 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL482709 | — | IC50 | = | 1189.0 | nM | 5.92 |
| CHEMBL482522 | — | IC50 | = | 1934.0 | nM | 5.71 |
| CHEMBL485323 | — | IC50 | = | 3000.0 | nM | 5.52 |