Assay Detail
Binding
CHEMBL956590
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Displacement of [3H]SUC from succinic acid binding site of gamma-hydroxybutyrate receptor in rat forebrain synaptic membranes
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.61 | 6.40 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514926 | — | — | 2 | 6.40 |
| CHEMBL472694 | — | — | 2 | 6.30 |
| CHEMBL446774 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514926 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL472694 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL446774 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL472694 | — | Activity | = | 17.0 | % | - |
| CHEMBL514926 | — | Activity | = | 26.0 | % | - |