Assay Detail
Binding
CHEMBL956660
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Binding affinity at rat GnRH receptor
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Non-peptide gonadotropin-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.46 | 9.70 |
| Ki | 2 | 7.36 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413245 | — | — | 1 | 9.70 |
| CHEMBL303274 | — | — | 1 | 9.20 |
| CHEMBL71917 | — | — | 1 | 7.22 |
| CHEMBL179691 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413245 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL303274 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL71917 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL179691 | — | Ki | = | 3000.0 | nM | 5.52 |