Assay Detail
Binding
CHEMBL956719
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membrane
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.62 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377153 | — | — | 1 | 8.52 |
| CHEMBL208905 | — | — | 1 | 8.40 |
| CHEMBL514077 | — | — | 1 | 8.37 |
| CHEMBL60322 | — | — | 1 | 8.24 |
| CHEMBL209007 | — | — | 1 | 8.05 |
| CHEMBL207087 | — | — | 1 | 7.77 |
| CHEMBL378298 | — | — | 1 | 7.72 |
| CHEMBL208735 | — | — | 1 | 7.72 |
| CHEMBL514202 | — | — | 1 | 7.62 |
| CHEMBL408589 | — | — | 1 | 7.58 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.44 |
| CHEMBL209060 | — | — | 1 | 7.40 |
| CHEMBL515933 | — | — | 1 | 7.39 |
| CHEMBL210107 | — | — | 1 | 7.20 |
| CHEMBL210157 | — | — | 1 | 7.16 |
| CHEMBL477871 | — | — | 1 | 7.11 |
| CHEMBL478068 | — | — | 1 | 6.96 |
| CHEMBL212039 | — | — | 1 | 6.64 |
| CHEMBL477945 | — | — | 1 | 6.64 |
| CHEMBL477027 | — | — | 1 | 6.46 |
| CHEMBL477034 | — | — | 1 | 6.44 |
| CHEMBL478251 | — | — | 1 | 6.41 |
| CHEMBL208785 | — | — | 1 | 6.32 |
| CHEMBL478269 | — | — | 1 | 6.30 |
| CHEMBL476169 | — | — | 1 | 6.24 |
| CHEMBL476010 | — | — | 1 | 6.24 |
| CHEMBL476217 | — | — | 1 | 6.00 |
| CHEMBL477414 | — | — | 1 | 5.82 |
| CHEMBL476221 | — | — | 1 | 5.76 |
| CHEMBL477427 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377153 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL208905 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL514077 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL60322 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL209007 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL207087 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL378298 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL208735 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL514202 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL408589 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL49 | BUSPIRONE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL209060 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL515933 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL210107 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL210157 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL477871 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL478068 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL212039 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL477945 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL477027 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL477034 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL478251 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL208785 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL478269 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL476169 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL476010 | — | Ki | = | 579.0 | nM | 6.24 |
| CHEMBL476217 | — | Ki | = | 1001.0 | nM | 6.00 |
| CHEMBL477414 | — | Ki | = | 1507.0 | nM | 5.82 |
| CHEMBL476221 | — | Ki | = | 1730.0 | nM | 5.76 |
| CHEMBL477427 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL478265 | — | Ki | = | 2013.0 | nM | 5.70 |
| CHEMBL476053 | — | Ki | = | 2087.0 | nM | 5.68 |
| CHEMBL514070 | — | Ki | = | 3553.0 | nM | 5.45 |
| CHEMBL476054 | — | Ki | = | 3675.0 | nM | 5.43 |
| CHEMBL477266 | — | Ki | = | 3775.0 | nM | 5.42 |
| CHEMBL477428 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL476062 | — | Ki | = | 7440.0 | nM | 5.13 |
| CHEMBL476261 | — | Ki | = | 7586.0 | nM | 5.12 |
| CHEMBL515930 | — | Ki | = | 8518.0 | nM | 5.07 |
| CHEMBL476260 | — | Ki | = | 10020.0 | nM | 5.00 |