Assay Detail
Functional
CHEMBL956747
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT2 cells after 5 days by chemiluminescence in presence of fetal bovine serum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.07 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513189 | — | — | 1 | 8.77 |
| CHEMBL513363 | — | — | 1 | 8.46 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 8.40 |
| CHEMBL512324 | — | — | 1 | 8.30 |
| CHEMBL451850 | — | — | 1 | 8.22 |
| CHEMBL469365 | — | — | 1 | 8.22 |
| CHEMBL470417 | — | — | 1 | 7.50 |
| CHEMBL469356 | — | — | 1 | 7.46 |
| CHEMBL470418 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513189 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL513363 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL512324 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL451850 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL469365 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL470417 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL469356 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL470418 | — | EC50 | = | 52.0 | nM | 7.28 |