Assay Detail
Functional
CHEMBL956748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT2 cells after 5 days by chemiluminescence in presence of human serum albumin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.70 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513189 | — | — | 1 | 7.94 |
| CHEMBL513363 | — | — | 1 | 7.92 |
| CHEMBL469365 | — | — | 1 | 7.77 |
| CHEMBL451850 | — | — | 1 | 7.75 |
| CHEMBL512324 | — | — | 1 | 7.75 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.70 |
| CHEMBL470417 | — | — | 1 | 7.05 |
| CHEMBL469356 | — | — | 1 | - |
| CHEMBL470418 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513189 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL513363 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL469365 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL451850 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL512324 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL470417 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL469356 | — | EC50 | - | — | - | |
| CHEMBL470418 | — | EC50 | - | — | - |