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Assay Detail

CHEMBL956777

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Functional
Antiviral activity against pseudotype HIV1 JRFL infected in human HeLa67 cells expressing CD4/CCR5 after 3 days by luciferase reporter gene assay
ChEMBL ↗
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type HeLa67
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns.
Meanwell NA, Wallace OB, Fang H, Wang H, Deshpande M, Wang T, Yin Z, Zhang Z, Pearce BC, James J, Yeung KS, Qiu Z, Kim Wright JJ, Yang Z, Zadjura L, Tweedie DL, Yeola S, Zhao F, Ranadive S, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, Colonno RJ, Lin PF.
Bioorg Med Chem Lett (2009) 19 : 1977 -1981
PubMed 19251416 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 57 7.60 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL522345 — — 1 10.22
CHEMBL523362 — — 1 10.22
CHEMBL492586 — — 1 10.15
CHEMBL522022 — — 1 9.89
CHEMBL494002 — — 1 9.89
CHEMBL494547 — — 1 9.85
CHEMBL522322 — — 1 9.64
CHEMBL494225 — — 1 9.46
CHEMBL495019 — — 1 9.38
CHEMBL493738 — — 1 9.35
CHEMBL445522 — — 1 9.30
CHEMBL523864 — — 1 9.28
CHEMBL522175 — — 1 9.25
CHEMBL523717 — — 1 9.15
CHEMBL493000 — — 1 8.77
CHEMBL495004 — — 1 8.72
CHEMBL135339 — — 1 8.59
CHEMBL523842 — — 1 8.37
CHEMBL522687 — — 1 8.36
CHEMBL492937 — — 1 8.35
CHEMBL494358 — — 1 8.31
CHEMBL523372 — — 1 8.18
CHEMBL522372 — — 1 8.14
CHEMBL524048 — — 1 8.09
CHEMBL495031 — — 1 7.76
CHEMBL524010 — — 1 7.68
CHEMBL494164 — — 1 7.64
CHEMBL494349 — — 1 7.62
CHEMBL493838 — — 1 7.37
CHEMBL523369 — — 1 7.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL522345 — EC50 = 0.06 nM 10.22
CHEMBL523362 — EC50 = 0.06 nM 10.22
CHEMBL492586 — EC50 = 0.07 nM 10.15
CHEMBL522022 — EC50 = 0.13 nM 9.89
CHEMBL494002 — EC50 = 0.13 nM 9.89
CHEMBL494547 — EC50 = 0.14 nM 9.85
CHEMBL522322 — EC50 = 0.23 nM 9.64
CHEMBL494225 — EC50 = 0.35 nM 9.46
CHEMBL495019 — EC50 = 0.42 nM 9.38
CHEMBL493738 — EC50 = 0.45 nM 9.35
CHEMBL445522 — EC50 = 0.5 nM 9.30
CHEMBL523864 — EC50 = 0.52 nM 9.28
CHEMBL522175 — EC50 = 0.56 nM 9.25
CHEMBL523717 — EC50 = 0.71 nM 9.15
CHEMBL493000 — EC50 = 1.7 nM 8.77
CHEMBL495004 — EC50 = 1.9 nM 8.72
CHEMBL135339 — EC50 = 2.59 nM 8.59
CHEMBL523842 — EC50 = 4.3 nM 8.37
CHEMBL522687 — EC50 = 4.4 nM 8.36
CHEMBL492937 — EC50 = 4.5 nM 8.35
CHEMBL494358 — EC50 = 4.9 nM 8.31
CHEMBL523372 — EC50 = 6.6 nM 8.18
CHEMBL522372 — EC50 = 7.3 nM 8.14
CHEMBL524048 — EC50 = 8.2 nM 8.09
CHEMBL495031 — EC50 = 17.4 nM 7.76
CHEMBL524010 — EC50 = 21.1 nM 7.68
CHEMBL494164 — EC50 = 23.1 nM 7.64
CHEMBL494349 — EC50 = 24.2 nM 7.62
CHEMBL493838 — EC50 = 42.8 nM 7.37
CHEMBL523369 — EC50 = 73.1 nM 7.14
CHEMBL495032 — EC50 = 89.5 nM 7.05
CHEMBL336293 — EC50 = 152.97 nM 6.82
CHEMBL492938 — EC50 = 149.8 nM 6.82
CHEMBL492947 — EC50 = 208.0 nM 6.68
CHEMBL522665 — EC50 = 265.0 nM 6.58
CHEMBL492948 — EC50 = 328.8 nM 6.48
CHEMBL493941 — EC50 = 395.0 nM 6.40
CHEMBL493934 — EC50 = 838.3 nM 6.08
CHEMBL492946 — EC50 = 952.2 nM 6.02
CHEMBL493942 — EC50 = 1090.3 nM 5.96
CHEMBL493011 — EC50 = 1450.0 nM 5.84
CHEMBL494134 — EC50 = 1548.6 nM 5.81
CHEMBL493184 — EC50 = 2650.0 nM 5.58
CHEMBL493535 — EC50 = 3800.0 nM 5.42
CHEMBL492965 — EC50 = 6760.0 nM 5.17
CHEMBL493172 — EC50 = 13750.0 nM 4.86
CHEMBL522010 — EC50 = 20137.4 nM 4.70
CHEMBL493338 — EC50 = 21100.0 nM 4.68
CHEMBL492951 — EC50 = 24857.5 nM 4.61
CHEMBL522666 — EC50 = 46451.2 nM 4.33