Assay Detail
Binding
CHEMBL956807
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Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.77 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 7.30 |
| CHEMBL16171 | WOGONIN | — | 1 | 5.97 |
| CHEMBL492959 | — | — | 1 | 5.42 |
| CHEMBL242078 | — | — | 1 | 5.39 |
| CHEMBL492554 | — | — | 1 | 5.34 |
| CHEMBL521653 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL16171 | WOGONIN | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL492959 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL242078 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL492554 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL521653 | — | IC50 | = | 6200.0 | nM | 5.21 |