Assay Detail
Binding
CHEMBL956810
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Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522456 | — | — | 1 | 8.70 |
| CHEMBL523819 | — | — | 1 | 8.57 |
| CHEMBL492594 | — | — | 1 | 8.37 |
| CHEMBL490937 | — | — | 1 | 8.37 |
| CHEMBL451113 | — | — | 1 | 8.32 |
| CHEMBL494398 | — | — | 1 | 8.32 |
| CHEMBL492778 | — | — | 1 | 8.27 |
| CHEMBL492388 | — | — | 1 | 8.21 |
| CHEMBL495034 | — | — | 1 | 8.14 |
| CHEMBL492377 | — | — | 1 | 8.09 |
| CHEMBL522539 | — | — | 1 | 8.06 |
| CHEMBL495369 | — | — | 1 | 8.04 |
| CHEMBL522489 | — | — | 1 | 8.00 |
| CHEMBL523339 | — | — | 1 | 7.77 |
| CHEMBL499973 | — | — | 1 | 7.52 |
| CHEMBL493971 | — | — | 1 | 7.50 |
| CHEMBL492766 | — | — | 1 | 7.41 |
| CHEMBL523364 | — | — | 1 | 7.36 |
| CHEMBL495036 | — | — | 1 | 7.33 |
| CHEMBL522513 | — | — | 1 | 7.29 |
| CHEMBL494175 | — | — | 1 | 7.27 |
| CHEMBL493970 | — | — | 1 | 7.27 |
| CHEMBL493998 | — | — | 1 | 7.23 |
| CHEMBL506812 | — | — | 1 | 7.03 |
| CHEMBL492779 | — | — | 1 | 6.89 |
| CHEMBL494018 | — | — | 1 | 6.80 |
| CHEMBL521862 | — | — | 1 | 6.80 |
| CHEMBL522866 | — | — | 1 | 6.80 |
| CHEMBL493997 | — | — | 1 | 6.57 |
| CHEMBL494174 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522456 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL523819 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL492594 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL490937 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL451113 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL494398 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL492778 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL492388 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL495034 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL492377 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL522539 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL495369 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL522489 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL523339 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL499973 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL493971 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL492766 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL523364 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL495036 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL522513 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL494175 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL493970 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL493998 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL506812 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL492779 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL494018 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL521862 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL522866 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL493997 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL494174 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL522192 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL523338 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL521844 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL522183 | — | IC50 | > | 1000.0 | nM | - |