Assay Detail
Functional
CHEMBL957134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against PERV infected in human 293T cells assessed as inhibition of proximal DNA synthesis after 24 hrs by RT-PCR
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Porcine endogenous retrovirus |
| Cell Type | 293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Porcine endogenous retrovirus (CHEMBL613016) ↗| Type | ORGANISM |
| Organism | Porcine endogenous retrovirus |
Publication
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.18 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.64 |
| CHEMBL298845 | — | — | 1 | 6.75 |
| CHEMBL482690 | — | — | 1 | 6.55 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.55 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.47 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.11 |
| CHEMBL124363 | CENSAVUDINE | 2.0 | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
| CHEMBL276563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL298845 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL482690 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL991 | STAVUDINE | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL124363 | CENSAVUDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL276563 | — | EC50 | > | 100000.0 | nM | - |