Assay Detail
Functional
CHEMBL957271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by microplate alamar blue assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.58 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.41 |
| CHEMBL487122 | — | — | 1 | 7.21 |
| CHEMBL482881 | — | — | 1 | 7.19 |
| CHEMBL519805 | — | — | 1 | 7.18 |
| CHEMBL485885 | — | — | 1 | 7.12 |
| CHEMBL482885 | — | — | 1 | 7.10 |
| CHEMBL483087 | — | — | 1 | 7.06 |
| CHEMBL521196 | — | — | 1 | 7.05 |
| CHEMBL518984 | — | — | 1 | 6.96 |
| CHEMBL520466 | — | — | 1 | 6.92 |
| CHEMBL486088 | — | — | 1 | 6.82 |
| CHEMBL487529 | — | — | 1 | 6.80 |
| CHEMBL529891 | — | — | 1 | 6.68 |
| CHEMBL520889 | — | — | 1 | 6.36 |
| CHEMBL486704 | — | — | 1 | 6.30 |
| CHEMBL515185 | — | — | 1 | 6.22 |
| CHEMBL521032 | — | — | 1 | 6.17 |
| CHEMBL483292 | — | — | 1 | 6.17 |
| CHEMBL519882 | — | — | 1 | 6.12 |
| CHEMBL486080 | — | — | 1 | 6.04 |
| CHEMBL486496 | — | — | 1 | 6.00 |
| CHEMBL528099 | — | — | 1 | 5.94 |
| CHEMBL482882 | — | — | 1 | 5.75 |
| CHEMBL487514 | — | — | 1 | 5.66 |
| CHEMBL486923 | — | — | 1 | 5.18 |
| CHEMBL486079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL487122 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL482881 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL519805 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL485885 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL482885 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL483087 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL521196 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL518984 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL520466 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL486088 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL487529 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL529891 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL520889 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL486704 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL515185 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL521032 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL483292 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL519882 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL486080 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL486496 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL528099 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL482882 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL487514 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL486923 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL486079 | — | IC50 | - | — | - |