Assay Detail
Binding
CHEMBL957333
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Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.48 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14690 | CLOBENPROPIT | — | 1 | 9.47 |
| CHEMBL18661 | IMMEPIP | — | 1 | 9.39 |
| CHEMBL82298 | IMMETHRIDINE | — | 1 | 9.10 |
| CHEMBL175782 | METHIMEPIP | — | 1 | 9.00 |
| CHEMBL494982 | — | — | 1 | 8.90 |
| CHEMBL449840 | — | — | 1 | 8.74 |
| CHEMBL268229 | — | — | 1 | 8.70 |
| CHEMBL451399 | — | — | 1 | 8.50 |
| CHEMBL495376 | — | — | 1 | 8.40 |
| CHEMBL278462 | CIPRALISANT | 2.0 | 1 | 8.40 |
| CHEMBL493014 | — | — | 1 | 8.35 |
| CHEMBL453433 | — | — | 1 | 7.60 |
| CHEMBL489493 | — | — | 1 | 7.49 |
| CHEMBL493012 | — | — | 1 | 7.48 |
| CHEMBL493813 | — | — | 1 | 7.40 |
| CHEMBL503542 | — | — | 1 | 7.39 |
| CHEMBL447687 | — | — | 1 | 7.25 |
| CHEMBL455266 | — | — | 1 | 7.05 |
| CHEMBL503691 | — | — | 1 | 6.81 |
| CHEMBL494421 | — | — | 1 | 6.79 |
| CHEMBL506072 | — | — | 1 | 6.59 |
| CHEMBL446011 | — | — | 1 | 6.38 |
| CHEMBL493013 | — | — | 1 | 6.37 |
| CHEMBL505616 | — | — | 1 | 6.27 |
| CHEMBL495158 | — | — | 1 | 6.15 |
| CHEMBL447902 | — | — | 1 | 6.09 |
| CHEMBL500635 | — | — | 1 | 5.76 |
| CHEMBL455475 | — | — | 1 | 5.60 |
| CHEMBL498149 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14690 | CLOBENPROPIT | Ki | = | 0.3388 | nM | 9.47 |
| CHEMBL18661 | IMMEPIP | Ki | = | 0.4074 | nM | 9.39 |
| CHEMBL82298 | IMMETHRIDINE | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL175782 | METHIMEPIP | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL494982 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL449840 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL268229 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL451399 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL495376 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL278462 | CIPRALISANT | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL493014 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL453433 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL489493 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL493012 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL493813 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL503542 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL447687 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL455266 | — | Ki | = | 89.13 | nM | 7.05 |
| CHEMBL503691 | — | Ki | = | 154.88 | nM | 6.81 |
| CHEMBL494421 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL506072 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL446011 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL493013 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL505616 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL495158 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL447902 | — | Ki | = | 812.83 | nM | 6.09 |
| CHEMBL500635 | — | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL455475 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL498149 | — | Ki | = | 2511.89 | nM | 5.60 |