Assay Detail
ADMET
CHEMBL957340
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Inhibition of CYP3A6 in human liver microsomes assessed as midazolam 1'-hydroxylase activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.78 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494982 | — | — | 1 | 6.06 |
| CHEMBL489493 | — | — | 1 | 5.96 |
| CHEMBL451399 | — | — | 1 | 5.79 |
| CHEMBL493014 | — | — | 1 | 5.73 |
| CHEMBL455475 | — | — | 1 | 5.60 |
| CHEMBL449840 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494982 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL489493 | — | IC50 | = | 1104.0 | nM | 5.96 |
| CHEMBL451399 | — | IC50 | = | 1639.0 | nM | 5.79 |
| CHEMBL493014 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL455475 | — | IC50 | = | 2522.0 | nM | 5.60 |
| CHEMBL449840 | — | IC50 | = | 2763.0 | nM | 5.56 |