Assay Detail
Functional
CHEMBL957342
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Antagonist activity at guinea pig histamine H3 receptor assessed as inhibition of electrically induced twitch contraction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.79 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494982 | — | — | 1 | 8.40 |
| CHEMBL493014 | — | — | 1 | 7.10 |
| CHEMBL489493 | — | — | 1 | 6.02 |
| CHEMBL455266 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494982 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL493014 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL489493 | — | Kd | = | 954.99 | nM | 6.02 |
| CHEMBL455266 | — | Kd | = | 2238.72 | nM | 5.65 |