Assay Detail
Binding
CHEMBL957461
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Inhibition of EGFR expressed in human tumor cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.67 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 6.70 |
| CHEMBL485320 | — | — | 1 | 6.52 |
| CHEMBL502015 | — | — | 1 | 5.91 |
| CHEMBL483313 | — | — | 1 | 5.88 |
| CHEMBL499344 | — | — | 1 | 5.78 |
| CHEMBL485321 | — | — | 1 | 5.66 |
| CHEMBL519147 | — | — | 1 | 5.50 |
| CHEMBL482489 | — | — | 1 | 5.47 |
| CHEMBL499345 | — | — | 1 | 5.37 |
| CHEMBL484109 | — | — | 1 | 5.33 |
| CHEMBL484108 | — | — | 1 | 5.32 |
| CHEMBL504416 | — | — | 1 | 4.64 |
| CHEMBL520803 | — | — | 1 | - |
| CHEMBL483312 | — | — | 1 | - |
| CHEMBL483108 | — | — | 1 | - |
| CHEMBL482715 | — | — | 1 | - |
| CHEMBL474538 | — | — | 1 | - |
| CHEMBL499067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL485320 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL502015 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL483313 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL499344 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL485321 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL519147 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL482489 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL499345 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL484109 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL484108 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL504416 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL520803 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL483312 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL483108 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL482715 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL474538 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL499067 | — | IC50 | > | 200000.0 | nM | - |