Assay Detail
Binding
CHEMBL957464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRbeta expressed in human tumor cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.69 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7724 | AG1295 | — | 1 | 5.21 |
| CHEMBL484108 | — | — | 1 | 4.96 |
| CHEMBL485320 | — | — | 1 | 4.93 |
| CHEMBL484109 | — | — | 1 | 4.86 |
| CHEMBL499067 | — | — | 1 | 4.11 |
| CHEMBL482715 | — | — | 1 | 4.05 |
| CHEMBL499344 | — | — | 1 | - |
| CHEMBL499345 | — | — | 1 | - |
| CHEMBL474538 | — | — | 1 | - |
| CHEMBL502015 | — | — | 1 | - |
| CHEMBL485321 | — | — | 1 | - |
| CHEMBL482489 | — | — | 1 | - |
| CHEMBL519147 | — | — | 1 | - |
| CHEMBL483313 | — | — | 1 | - |
| CHEMBL483108 | — | — | 1 | - |
| CHEMBL504416 | — | — | 1 | - |
| CHEMBL483312 | — | — | 1 | - |
| CHEMBL520803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7724 | AG1295 | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL484108 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL485320 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL484109 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL499067 | — | IC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL482715 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL499344 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL499345 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL474538 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL502015 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL485321 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL482489 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL519147 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL483313 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL483108 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL504416 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL483312 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL520803 | — | IC50 | = | 100400.0 | nM | - |