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Assay Detail

CHEMBL957933

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ADMET
Antiproliferative activity against mouse J774.A1 cells after 72 hrs by MTT conversion assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type J774.A1
Confidence 1 — Organism
Curated By Autocuration

Target

J774.A1 (CHEMBL614040)
Type CELL-LINE
Organism Mus musculus

Publication

Antiproliferative oleanane saponins from Meryta denhamii.
Cioffi G, Dal Piaz F, Vassallo A, Venturella F, De Caprariis P, De Simone F, De Tommasi N.
J Nat Prod (2008) 71 : 1000 -1004
PubMed 18442289 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.99 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1425 MERCAPTOPURINE ANHYDROUS 4.0 1 8.52
CHEMBL486881 1 6.72
CHEMBL507138 1 6.50
CHEMBL506188 1 5.60
CHEMBL449916 1 5.52
CHEMBL499677 1 5.44
CHEMBL507155 1 5.41
CHEMBL502666 1 5.16
CHEMBL524337 1 5.05
CHEMBL509910 1 -
CHEMBL452712 1 -
CHEMBL505247 1 -
CHEMBL448367 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1425 MERCAPTOPURINE ANHYDROUS IC50 = 3.0 nM 8.52
CHEMBL486881 IC50 = 190.0 nM 6.72
CHEMBL507138 IC50 = 320.0 nM 6.50
CHEMBL506188 IC50 = 2500.0 nM 5.60
CHEMBL449916 IC50 = 3000.0 nM 5.52
CHEMBL499677 IC50 = 3600.0 nM 5.44
CHEMBL507155 IC50 = 3900.0 nM 5.41
CHEMBL502666 IC50 = 6900.0 nM 5.16
CHEMBL524337 IC50 = 9000.0 nM 5.05
CHEMBL509910 IC50 - -
CHEMBL452712 IC50 - -
CHEMBL505247 IC50 - -
CHEMBL448367 IC50 - -