Assay Detail
Functional
CHEMBL958064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 5.61 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239151 | — | — | 1 | 6.57 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 6.52 |
| CHEMBL488132 | — | — | 1 | 6.21 |
| CHEMBL507060 | — | — | 1 | 6.18 |
| CHEMBL507282 | DENUFOSOL | 3.0 | 1 | 6.02 |
| CHEMBL505403 | — | — | 1 | 5.99 |
| CHEMBL509434 | — | — | 1 | 5.98 |
| CHEMBL221326 | DIQUAFOSOL | 4.0 | 1 | 5.94 |
| CHEMBL217803 | — | — | 1 | 5.82 |
| CHEMBL503798 | — | — | 1 | 5.69 |
| CHEMBL527872 | — | — | 1 | 5.33 |
| CHEMBL484290 | — | — | 1 | 5.29 |
| CHEMBL503256 | — | — | 1 | 5.26 |
| CHEMBL521451 | — | — | 1 | 5.19 |
| CHEMBL482485 | — | — | 1 | 5.17 |
| CHEMBL482683 | — | — | 1 | 5.13 |
| CHEMBL483502 | — | — | 1 | 5.12 |
| CHEMBL499138 | — | — | 1 | 5.11 |
| CHEMBL444212 | — | — | 1 | 5.09 |
| CHEMBL482895 | — | — | 1 | 5.09 |
| CHEMBL483913 | — | — | 1 | 5.09 |
| CHEMBL484105 | — | — | 1 | - |
| CHEMBL519835 | — | — | 1 | - |
| CHEMBL482472 | — | — | 1 | - |
| CHEMBL484295 | — | — | 1 | - |
| CHEMBL519991 | — | — | 1 | - |
| CHEMBL474887 | — | — | 1 | - |
| CHEMBL448985 | — | — | 1 | - |
| CHEMBL500840 | — | — | 1 | - |
| CHEMBL508122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239151 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL488132 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL507060 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL507282 | DENUFOSOL | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL505403 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL509434 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL221326 | DIQUAFOSOL | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL217803 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL503798 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL527872 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL484290 | — | EC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL503256 | — | EC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL521451 | — | EC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL482485 | — | EC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL482683 | — | EC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL483502 | — | EC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL499138 | — | EC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL444212 | — | EC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL482895 | — | EC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL483913 | — | EC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL484105 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL519835 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL482472 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL484295 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL519991 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL474887 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL448985 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL500840 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL508122 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL454230 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | > | 10000.0 | nM | - |
| CHEMBL502712 | — | EC50 | > | 10000.0 | nM | - |