Assay Detail
Functional
CHEMBL958144
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Inhibition of CXCL12-induced actin polymerization in human whole blood
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.50 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452864 | — | — | 1 | 7.50 |
| CHEMBL460491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452864 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL460491 | — | IC50 | - | — | - |