Assay Detail
Functional
CHEMBL958175
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Antiviral activity against X4-tropic HIV1 3B assessed as inhibition of viral attachment
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.59 | 8.52 |
| IC90 | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | 4.0 | 2 | 8.52 |
| CHEMBL460491 | — | — | 2 | 8.15 |
| CHEMBL518501 | — | — | 2 | 8.00 |
| CHEMBL452864 | — | — | 2 | 7.40 |
| CHEMBL541728 | — | — | 2 | 7.40 |
| CHEMBL508054 | — | — | 2 | 7.30 |
| CHEMBL460299 | — | — | 2 | 6.33 |
| CHEMBL452868 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL460491 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL518501 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL452864 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL541728 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL508054 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL460299 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL452864 | — | IC90 | = | 720.0 | nM | - |
| CHEMBL518501 | — | IC90 | = | 130.0 | nM | - |
| CHEMBL460491 | — | IC90 | = | 100.0 | nM | - |
| CHEMBL460299 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL541728 | — | IC90 | = | 1140.0 | nM | - |
| CHEMBL508054 | — | IC90 | = | 820.0 | nM | - |
| CHEMBL452868 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL452868 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL18442 | PLERIXAFOR | IC90 | = | 50.0 | nM | - |