Assay Detail
Functional
CHEMBL958385
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.66 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630 | — | — | 1 | 8.26 |
| CHEMBL523342 | — | — | 1 | 8.09 |
| CHEMBL475811 | — | — | 1 | 8.04 |
| CHEMBL492914 | — | — | 1 | 8.02 |
| CHEMBL446386 | — | — | 1 | 8.00 |
| CHEMBL492326 | — | — | 1 | 7.91 |
| CHEMBL492722 | — | — | 1 | 7.91 |
| CHEMBL453384 | — | — | 1 | 7.84 |
| CHEMBL523677 | — | — | 1 | 7.82 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.70 |
| CHEMBL492307 | — | — | 1 | 7.26 |
| CHEMBL502137 | — | — | 1 | 7.20 |
| CHEMBL492913 | — | — | 1 | 6.84 |
| CHEMBL475810 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL523342 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL475811 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL492914 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL446386 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL492326 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL492722 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL453384 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL523677 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL492307 | — | IC50 | = | 54.5 | nM | 7.26 |
| CHEMBL502137 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL492913 | — | IC50 | = | 144.3 | nM | 6.84 |
| CHEMBL475810 | — | IC50 | = | 485.0 | nM | 6.31 |