Compound Detail
CHEMBL492914
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Basic Information
| ChEMBL ID | CHEMBL492914 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RMYFRGYSVISRAH-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
415.4
MW (Da)
5.42
ALogP
4
HBA
1
HBD
31.4
PSA (Ų)
0.60
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 8.02 | 7.8033 | 9.6 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 9.6 | nM | 8.02 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 | 19284751 |
| Plasmodium falciparum | IC50 | = | 10.3 | nM | 7.99 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM6 | 19284751 |
| Plasmodium falciparum | IC50 | = | 39.7 | nM | 7.4 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 | 19284751 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19284751 | 10.1021/jm8012757 | Plasmodium falciparum | 3 |
Data from ChEMBL 36 via Core Engine