Assay Detail
Functional
CHEMBL958495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 bearing protease gene with P25 mutation infected in human MT4 cells after 5 days by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.79 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470508 | — | — | 1 | 7.35 |
| CHEMBL507731 | — | — | 1 | 6.99 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 6.53 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 6.29 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470508 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL507731 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 298.0 | nM | 6.53 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 515.0 | nM | 6.29 |
| CHEMBL729 | LOPINAVIR | EC50 | > | 10000.0 | nM | - |