Assay Detail
Functional
CHEMBL958577
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Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell survival after 2 days by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Hepa-1c1c7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.85 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 4.96 |
| CHEMBL457943 | TEPHROPURPURIN | — | 1 | 4.87 |
| CHEMBL458131 | PONGAMOL | — | 1 | 4.73 |
| CHEMBL457942 | — | — | 1 | - |
| CHEMBL516163 | — | — | 1 | - |
| CHEMBL224157 | LANCEOLATIN B | — | 1 | - |
| CHEMBL334918 | MAACKIAIN | — | 1 | - |
| CHEMBL458847 | — | — | 1 | - |
| CHEMBL238845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48802 | SULFORAPHANE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL457943 | TEPHROPURPURIN | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL458131 | PONGAMOL | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL457942 | — | IC50 | > | 63700.0 | nM | - |
| CHEMBL516163 | — | IC50 | > | 50700.0 | nM | - |
| CHEMBL224157 | LANCEOLATIN B | IC50 | > | 76300.0 | nM | - |
| CHEMBL334918 | MAACKIAIN | IC50 | > | 70400.0 | nM | - |
| CHEMBL458847 | — | IC50 | > | 63700.0 | nM | - |
| CHEMBL238845 | — | IC50 | > | 74000.0 | nM | - |