Assay Detail

CHEMBL958592

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Functional

Cytotoxicity against human HL60 cells by SRB assay

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

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Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Autocuration

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.

Zhao Y, Hao X, Lu W, Cai J, Yu H, Sevénet T, Guéritte F.
J Nat Prod (2002) 65 : 902 -908
PubMed 12088436 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.05	5.17

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL464449	NELUMOL A	—	1	5.17
CHEMBL464705	NELUMAL A	—	1	4.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL464449	NELUMOL A	IC50	=	6700.0	nM	5.17
CHEMBL464705	NELUMAL A	IC50	=	12000.0	nM	4.92