Assay Detail
Binding
CHEMBL958719
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Inhibition of uPA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent developments in fragment-based drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.42 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253825 | — | — | 1 | 7.14 |
| CHEMBL126589 | — | — | 1 | 3.70 |
| CHEMBL147507 | (R)-MEXILETINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253825 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL126589 | — | IC50 | = | 200000.0 | nM | 3.70 |
| CHEMBL147507 | (R)-MEXILETINE | IC50 | > | 1000000.0 | nM | - |