Assay Detail
Binding
CHEMBL959082
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Binding affinity to influenza A virus A/chicken/Germany/27 H7N7 weybridge strain M2 ion channel expressed in Escherichia coli
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.74 | 6.50 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | 4.0 | 1 | 6.50 |
| CHEMBL473915 | — | — | 1 | 6.41 |
| CHEMBL473914 | — | — | 1 | 5.94 |
| CHEMBL447911 | — | — | 1 | 5.63 |
| CHEMBL461320 | — | — | 1 | 5.44 |
| CHEMBL506444 | — | — | 1 | 5.17 |
| CHEMBL461321 | — | — | 1 | 5.06 |
| CHEMBL460096 | — | — | 1 | - |
| CHEMBL503959 | — | — | 1 | - |
| CHEMBL500891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL473915 | — | Kd | = | 390.0 | nM | 6.41 |
| CHEMBL473914 | — | Kd | = | 1160.0 | nM | 5.94 |
| CHEMBL447911 | — | Kd | = | 2360.0 | nM | 5.63 |
| CHEMBL461320 | — | Kd | = | 3600.0 | nM | 5.44 |
| CHEMBL506444 | — | Kd | = | 6700.0 | nM | 5.17 |
| CHEMBL461321 | — | Kd | = | 8710.0 | nM | 5.06 |
| CHEMBL460096 | — | Kd | > | 26000.0 | nM | - |
| CHEMBL503959 | — | Activity | - | — | - | |
| CHEMBL500891 | — | Activity | - | — | - |