Assay Detail
Binding
CHEMBL959146
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Inhibition of mitochondrial complex 1 in bovine heart mitochondria assessed as effect on rate of NADH oxidation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Heart |
| Subcellular | Mitochondria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of pyridazinone analogues as potential cardiac positron emission tomography tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.33 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225963 | PYRIDABEN | — | 1 | 8.10 |
| CHEMBL493613 | — | — | 1 | 8.10 |
| CHEMBL243937 | — | — | 1 | 8.05 |
| CHEMBL493612 | — | — | 1 | 8.00 |
| CHEMBL494622 | FLURPIRIDAZ | 4.0 | 1 | 7.96 |
| CHEMBL468381 | — | — | 1 | 7.96 |
| CHEMBL493593 | — | — | 1 | 7.82 |
| CHEMBL429023 | ROTENONE | — | 1 | 7.80 |
| CHEMBL523353 | — | — | 1 | 7.80 |
| CHEMBL494755 | — | — | 1 | 7.77 |
| CHEMBL494640 | — | — | 1 | 7.68 |
| CHEMBL494756 | — | — | 1 | 7.57 |
| CHEMBL494623 | — | — | 1 | 7.55 |
| CHEMBL522356 | — | — | 1 | 7.51 |
| CHEMBL505265 | — | — | 1 | 7.33 |
| CHEMBL356903 | — | — | 1 | 7.28 |
| CHEMBL493423 | — | — | 1 | 7.22 |
| CHEMBL500046 | — | — | 1 | 7.19 |
| CHEMBL243282 | FENAZAQUIN | — | 1 | 7.05 |
| CHEMBL521999 | — | — | 1 | 6.66 |
| CHEMBL524041 | — | — | 1 | 6.60 |
| CHEMBL445251 | — | — | 1 | 6.55 |
| CHEMBL494754 | — | — | 1 | 6.15 |
| CHEMBL523878 | — | — | 1 | 6.07 |
| CHEMBL493406 | — | — | 1 | 5.40 |
| CHEMBL493629 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225963 | PYRIDABEN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL493613 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL243937 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL493612 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL494622 | FLURPIRIDAZ | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL468381 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL493593 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL429023 | ROTENONE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL523353 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL494755 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL494640 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL494756 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL494623 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL522356 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL505265 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL356903 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL493423 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL500046 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL243282 | FENAZAQUIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL521999 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL524041 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL445251 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL494754 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL523878 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL493406 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL493629 | — | IC50 | > | 4000.0 | nM | - |