Assay Detail
Binding
CHEMBL959280
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Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.35 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455271 | — | — | 1 | 7.31 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.03 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 5.21 |
| CHEMBL262628 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455271 | — | Ki | = | 48.9 | nM | 7.31 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL262628 | — | Ki | = | 9000.0 | nM | 5.05 |