Assay Detail
Binding
CHEMBL959526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinuclidine derivatives as potential antiparasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.87 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453439 | — | — | 1 | 6.60 |
| CHEMBL478348 | — | — | 1 | 6.18 |
| CHEMBL478981 | — | — | 1 | 5.55 |
| CHEMBL259665 | — | — | 1 | 5.16 |
| CHEMBL517819 | — | — | 1 | - |
| CHEMBL478531 | — | — | 1 | - |
| CHEMBL391926 | — | — | 1 | - |
| CHEMBL477079 | — | — | 1 | - |
| CHEMBL477327 | — | — | 1 | - |
| CHEMBL517203 | — | — | 1 | - |
| CHEMBL477506 | — | — | 1 | - |
| CHEMBL445817 | — | — | 1 | - |
| CHEMBL478339 | — | — | 1 | - |
| CHEMBL479211 | — | — | 1 | - |
| CHEMBL479212 | — | — | 1 | - |
| CHEMBL518600 | — | — | 1 | - |
| CHEMBL478347 | — | — | 1 | - |
| CHEMBL478532 | — | — | 1 | - |
| CHEMBL478533 | — | — | 1 | - |
| CHEMBL517050 | — | — | 1 | - |
| CHEMBL516895 | — | — | 1 | - |
| CHEMBL478112 | — | — | 1 | - |
| CHEMBL477492 | — | — | 1 | - |
| CHEMBL478723 | — | — | 1 | - |
| CHEMBL478724 | — | — | 1 | - |
| CHEMBL477326 | — | — | 1 | - |
| CHEMBL477305 | — | — | 1 | - |
| CHEMBL479189 | — | — | 1 | - |
| CHEMBL518134 | — | — | 1 | - |
| CHEMBL477322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453439 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL478348 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL478981 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL259665 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL445817 | — | IC50 | - | — | - | |
| CHEMBL478340 | — | IC50 | - | — | - | |
| CHEMBL478339 | — | IC50 | - | — | - | |
| CHEMBL479211 | — | IC50 | - | — | - | |
| CHEMBL479212 | — | IC50 | - | — | - | |
| CHEMBL518600 | — | IC50 | - | — | - | |
| CHEMBL478347 | — | IC50 | - | — | - | |
| CHEMBL478531 | — | IC50 | - | — | - | |
| CHEMBL478530 | — | IC50 | - | — | - | |
| CHEMBL478350 | — | IC50 | - | — | - | |
| CHEMBL478349 | — | IC50 | - | — | - | |
| CHEMBL515183 | — | IC50 | - | — | - | |
| CHEMBL505301 | — | IC50 | - | — | - | |
| CHEMBL516436 | — | IC50 | - | — | - | |
| CHEMBL442578 | — | IC50 | - | — | - | |
| CHEMBL479223 | — | IC50 | - | — | - | |
| CHEMBL443678 | — | IC50 | - | — | - | |
| CHEMBL344327 | — | IC50 | - | — | - | |
| CHEMBL109405 | — | IC50 | - | — | - | |
| CHEMBL516895 | — | IC50 | - | — | - | |
| CHEMBL477322 | — | IC50 | - | — | - | |
| CHEMBL518134 | — | IC50 | - | — | - | |
| CHEMBL479189 | — | IC50 | - | — | - | |
| CHEMBL477305 | — | IC50 | - | — | - | |
| CHEMBL477326 | — | IC50 | - | — | - | |
| CHEMBL478724 | — | IC50 | - | — | - | |
| CHEMBL478723 | — | IC50 | - | — | - | |
| CHEMBL477492 | — | IC50 | - | — | - | |
| CHEMBL478112 | — | IC50 | - | — | - | |
| CHEMBL477506 | — | IC50 | - | — | - | |
| CHEMBL517050 | — | IC50 | - | — | - | |
| CHEMBL478533 | — | IC50 | - | — | - | |
| CHEMBL478532 | — | IC50 | - | — | - | |
| CHEMBL517819 | — | IC50 | - | — | - | |
| CHEMBL391926 | — | IC50 | - | — | - | |
| CHEMBL477079 | — | IC50 | - | — | - | |
| CHEMBL477327 | — | IC50 | - | — | - | |
| CHEMBL517203 | — | IC50 | - | — | - |