Assay Detail
Binding
CHEMBL959570
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Inhibition of MET
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.56 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462622 | — | — | 1 | 9.00 |
| CHEMBL462624 | — | — | 1 | 9.00 |
| CHEMBL509101 | — | — | 1 | 8.74 |
| CHEMBL461583 | — | — | 1 | 8.59 |
| CHEMBL518656 | — | — | 1 | 8.57 |
| CHEMBL461582 | — | — | 1 | 8.49 |
| CHEMBL517293 | — | — | 1 | 8.47 |
| CHEMBL462623 | — | — | 1 | 8.47 |
| CHEMBL460502 | — | — | 1 | 8.42 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.41 |
| CHEMBL516790 | — | — | 1 | 8.35 |
| CHEMBL515858 | — | — | 1 | 8.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462622 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL462624 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL509101 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL461583 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL518656 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL461582 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL517293 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL462623 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL460502 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL516790 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL515858 | — | IC50 | = | 5.9 | nM | 8.23 |