Assay Detail
Functional
CHEMBL959571
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Antiproliferative activity against Met-dependent human GTL16 cells after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GTL 16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.88 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518656 | — | — | 1 | 7.64 |
| CHEMBL462622 | — | — | 1 | 7.51 |
| CHEMBL462624 | — | — | 1 | 7.24 |
| CHEMBL509101 | — | — | 1 | 7.22 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 7.00 |
| CHEMBL462623 | — | — | 1 | 6.92 |
| CHEMBL461582 | — | — | 1 | 6.85 |
| CHEMBL516790 | — | — | 1 | 6.77 |
| CHEMBL460502 | — | — | 1 | 6.68 |
| CHEMBL461583 | — | — | 1 | 6.60 |
| CHEMBL517293 | — | — | 1 | 6.55 |
| CHEMBL515858 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518656 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL462622 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL462624 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL509101 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL462623 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL461582 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL516790 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL460502 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL461583 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL517293 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL515858 | — | IC50 | = | 2800.0 | nM | 5.55 |