Assay Detail
Binding
CHEMBL959752
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Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHOK1 cell membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation of piperazine derivatives as 5-HT7 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.33 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497749 | — | — | 1 | 8.34 |
| CHEMBL495678 | — | — | 1 | 7.54 |
| CHEMBL495250 | — | — | 1 | 7.41 |
| CHEMBL493816 | — | — | 1 | 7.41 |
| CHEMBL493625 | — | — | 1 | 7.36 |
| CHEMBL495212 | — | — | 1 | 6.67 |
| CHEMBL427518 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497749 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL495678 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL495250 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL493816 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL493625 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL495212 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL427518 | — | IC50 | = | 272.0 | nM | 6.57 |