Assay Detail
Functional
CHEMBL959882
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Antiviral activity against influenza A virus H3N2 X31(A/Hong kong/1/68 x A/Puerto Rico/8/34 reassortant ) in MDCK cells assessed as reduction of virus-induced cytopathogenicity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.36 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473914 | — | — | 1 | 5.75 |
| CHEMBL500891 | — | — | 1 | 4.97 |
| CHEMBL461320 | — | — | 1 | - |
| CHEMBL506444 | — | — | 1 | - |
| CHEMBL461321 | — | — | 1 | - |
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473914 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL500891 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL461320 | — | EC50 | < | 2000.0 | nM | - |
| CHEMBL506444 | — | EC50 | < | 1900.0 | nM | - |
| CHEMBL461321 | — | EC50 | < | 1700.0 | nM | - |
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | EC50 | < | 900.0 | nM | - |