Assay Detail
Binding
CHEMBL960033
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Inhibition of human HDAC3
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.00 |
| CHEMBL471042 | — | — | 1 | 6.80 |
| CHEMBL471043 | — | — | 1 | 6.18 |
| CHEMBL471041 | — | — | 1 | 5.55 |
| CHEMBL470843 | — | — | 1 | 5.50 |
| CHEMBL472631 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL471042 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL471043 | — | IC50 | = | 659.0 | nM | 6.18 |
| CHEMBL471041 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL470843 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL472631 | — | IC50 | = | 4080.0 | nM | 5.39 |