Assay Detail
Functional
CHEMBL960139
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Antiproliferative activity against human HCT116 cells after 3 days
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new camptothecin analogs with improved antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.45 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492573 | — | — | 1 | 10.70 |
| CHEMBL492975 | — | — | 1 | 10.30 |
| CHEMBL493935 | — | — | 1 | 9.92 |
| CHEMBL492381 | — | — | 1 | 9.60 |
| CHEMBL493949 | — | — | 1 | 9.44 |
| CHEMBL493342 | — | — | 1 | 9.44 |
| CHEMBL493368 | — | — | 1 | 9.40 |
| CHEMBL523188 | — | — | 1 | 9.36 |
| CHEMBL523182 | — | — | 1 | 9.28 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 9.26 |
| CHEMBL492974 | — | — | 1 | 9.07 |
| CHEMBL493146 | — | — | 1 | 8.66 |
| CHEMBL493367 | — | — | 1 | 8.44 |
| CHEMBL524170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492573 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL492975 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL493935 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL492381 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL493949 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL493342 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL493368 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL523188 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL523182 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL492974 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL493146 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL493367 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL524170 | — | IC50 | < | 0.04 | nM | - |