Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL960151

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML.
J Med Chem (2009) 52 : 2384 -2392
PubMed 19326916 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.29 7.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL490644 1 7.94
CHEMBL506875 1 7.80
CHEMBL523121 1 7.74
CHEMBL489028 1 7.66
CHEMBL489249 1 7.58
CHEMBL490645 1 7.41
CHEMBL395933 1 6.91
CHEMBL489447 1 6.74
CHEMBL445334 1 6.66
CHEMBL240774 1 6.44
CHEMBL393492 1 -
CHEMBL521973 1 -
CHEMBL394080 1 -
CHEMBL489029 1 -
CHEMBL522417 1 -
CHEMBL521574 1 -
CHEMBL489448 1 -
CHEMBL489255 1 -
CHEMBL455210 1 -
CHEMBL489256 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL490644 Ki = 11.5 nM 7.94
CHEMBL506875 Ki = 16.0 nM 7.80
CHEMBL523121 Ki = 18.1 nM 7.74
CHEMBL489028 Ki = 22.0 nM 7.66
CHEMBL489249 Ki = 26.0 nM 7.58
CHEMBL490645 Ki = 39.0 nM 7.41
CHEMBL395933 Ki = 124.0 nM 6.91
CHEMBL489447 Ki = 181.0 nM 6.74
CHEMBL445334 Ki = 219.0 nM 6.66
CHEMBL240774 Ki = 360.0 nM 6.44
CHEMBL393492 Ki > 1000.0 nM -
CHEMBL521973 Ki > 1000.0 nM -
CHEMBL394080 Ki > 1000.0 nM -
CHEMBL489029 Ki > 1000.0 nM -
CHEMBL522417 Ki > 1000.0 nM -
CHEMBL521574 Ki > 1000.0 nM -
CHEMBL489448 Ki > 1000.0 nM -
CHEMBL489255 Ki > 1000.0 nM -
CHEMBL455210 Ki > 1000.0 nM -
CHEMBL489256 Ki > 1000.0 nM -